What is adhesion? How do you measure it? How do you control it? What are the differences between adhesion and non-adhesion, adhesion and adhesive strength? What is the role of mechanical interlocking, intermolecular forces, and actual contact area between adherents? What are the dissipative and rupture mechanisms activated during the separation of an interface or an interphase? The glass, tyres, wood, metal, ceramics, paints, coatings, cosmetics and medical devices industries are interested in these simple, yet complex questions. The science of adhesion is a multidisciplinary science, bringing together knowledge in the chemistry and physics of polymers, materials, surfaces and interfaces. Moreover, the understanding of adhesion mechanisms often involves the implementation of advanced spectroscopic or analytical methods. As a result, the global understanding of an adhesion phenomenon, and its control, can be only multidisciplinary and multiscalar. Recent advances in chemistry, physics, mechanics, and surface and interface spectroscopy help the understanding of adhesion mechanisms. This science has progressed considerably over the past ten years and this master class aims to deliver, on the basis of practical “business” examples, a current panorama of the concepts and experiences to master in order to control adhesion.